Cell Therapies-Engineered Cartilage Tissue-New Horizons

Engineered T cell therapies.

Alongside advancements in gene therapy for inherited immune disorders, the need for effective alternative therapeutic options for other conditions has resulted in an expansion in the field of research for T cell gene therapy. T cells are easily obtained and can be induced to divide robustly ex vivo, a characteristic that allows them to be highly permissible to viral vector-mediated introduction...

New Horizons in Articular Cartilage Repair

Articular cartilage rarely reforms a functional hyaline surface after injury. Most simple cartilage lacerative injuries reach a benign nonhealing phase, which remains unchanged over time. Deeper cartilage lesions, which violate the tide-mark and extend into the subchondral bone plate, result in an improved healing response. This is largely because of the proliferation of undifferentiated mesenc...

New horizons in pulmonary arterial hypertension therapies.

Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction and vascular remodelling. There are three well-known pathways that contribute to the pathogenesis of PAH: endothelin, nitric oxide and prostacyclin. Treatments targeting these pathways are well established in clinical practice, such as endothelin receptor antagonists, phosphodiesterase type-5 inhibitors an...

Decellularized Cartilage as a Scaffold for Tissue Engineered Cartilage

The Tissue Engineered Approaches for Cartilage Repair

Technological improvements in biology, medicine, chemistry, engineering and material science have allowed deeper insights into the architectural and molecular organization levels of tissues and materials, providing innovative approaches and tools for medical treatments. One of the therapeutic targets that may benefit from these new issues is damaged human articular cartilage, a tissue unable to...